Tacrolimus belongs to the so called macrolides. The substance can reduce the immune reactions of the body. Hence, it is used, among others, for individuals who have received organ transplants. In the treatment of neurodermitis, tacrolimus also reduces the immune response in acute phases of the disease which leads to an improvement of the symptoms. Despite that fact, the basic cause of neurodermitis cannot be treated. Yet, the sensitivity of the skin to infections is increased similar to the cortisone treatment. In contrast to cortisone however tacrolimus will not cause atrophic skin.
R. Fölster-Holst, Hautfreund 2000 (5), 11-14
P. Högger, Pharmazeutische Zeitung 146 (30), 2626-2627 (2001)