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Benefits of lamellar preparations for skin care, skin protection and dermatological therapies
 
Lecture held at the 17th annual meeting of the Society of Dermopharmacy at Mainz on March 23, 2013


Lamellar cream bases are appropriate formulations for skin care but also for skin protection purposes due to their chemical composition and their physical characteristics1,2,3. Professional associations recommend the preparations for the occupational skin protection in particular for the contact with different working substances4 and for recovery purposes; meanwhile, skin protection and skin recovery are rated equally5,6.
The relationship of lamellar creams with the lamellar structures of liposomes and nanodispersions based on phospholipids7, allows a smooth transition from skin protection to an active agent dominated skin care8. As regards the skin care, the skin barrier can be opened for the penetration of active agents and then closed again without the risk of counterproductive occlusive conditions. This specific technique is rather significant for professional treatments9.
The washout effect of lamellar cream bases in comparison to typical O/W emulsions is negligible with the result that the natural barrier structure with its characteristic conformation is largely maintained, a fact that is particularly important for problem skins. Hence they are appropriate formulations for the treatment of barrier disorders10. As far as the supportive prevention is concerned, individual cosmetic formulations in strict accordance with the German Cosmetic Regulation (KVO) can be prepared in the pharmacy11,12,13. Regarding dermatological prescriptions14,15,16, the German Ordinance on the Operation of Pharmacies as to the definition of additives (cream bases) and pharmaceutical active agents has to be considered17,18. A number of active agents serve for dermatological but also for cosmetic preparations19; in these cases the respective regulation regarding the claims should be observed.
Topical treatments can either be realized on a modular base by preparing individual formulations or alternatively by applying finished lamellar products. In the foreground are preparations for the care of barrier, cornification and connective tissue disorders as well as sun protection preparations. The transition of the dermatological therapy to a cosmetic prevention can easily be realized.
A comparison of cosmetic and dermatological formulations based on medical indications shows that various skin disorders already can be cured by applying appropriate skin care preparations20,21,22. A characteristic is the release of active agents from lamellar preparations: liposomes with polar active agents, such as azelaic acid help avoid high initial dosages. Vitamin-A derivatives from phospholipidic nanodispersions show typical Vitamin-A acid effects already in low concentrations23. Depot effects can be observed with cream bases which allow time-dependent dosage reductions24.
The current state of knowledge on lamellar formulations is reviewed25 with reference to a symposium on this subject in May 201326.

  1. Lautenschläger H, Albrecht M, Bohn M, Weisser M, Wasserhaltige Hautschutzpräparate zur Prävention von Hautschäden, DE 19857492 (14.12.98) (Lautenschläger, Kuhs GmbH)
  2. Lautenschläger H, Universelle Basiscremes mit Membran-Struktur für Hautpflege, Hautschutz und Dermatika, Österreichische Apothekerzeitung 2002;56;14:679
  3. Derma Membran Struktur®: Fortschritt im betrieblichen Hautschutz, Symposium Medical 2001;12;5:37
  4. Lautenschläger H, Kühlschmierstoffe und Hautschutz - neue Perspektiven, Mineralöltechnik 1998;5:1-16
  5. Lautenschläger, Kühlschmierstoffe - Forderungen des modernen Hautschutzes, Mineralöltechnik 1996;6:1-19
  6. dermaviduals®-Hautschutzplan 2013:1-3 (für Betriebe)
  7. Lautenschläger H, Liposomes, Handbook of Cosmetic Science and Technology (Barel AO, Paye M and Maibach HI), CRC Press Taylor & Francis Group, Boca Raton 2006:155-163
  8. Lautenschläger H, Albrecht M, Bohn M, Weisser M, Hautschutzpräparate zur Prävention von Hautschäden, DE 19857490 (14.12.98) (Lautenschläger, Kuhs GmbH)
  9. Lautenschläger H, Angewandte Korneotherapie in der Hautpflege - ein Leitfaden für die Anti-Aging-Behandlung, Ästhetische Dermatologie (mdm) 2007;3:8-16
  10. Lautenschläger H, Dem Juckreiz den Kampf ansagen, LiBK - Lehrer im Berufsfeld Hautpflege 2012;4:10-11
  11. Neues Rezeptur-Formularium (NRF): Kosmetika-Herstellung in der Apotheke, Govi-Verlag, 2010:1-3
  12. CPNP-Portal, http://ec.europa.eu/consumers/sectors/cosmetics/cpnp/index_en.htm
  13. Leitlinien zur Einhaltung der Verordnung 1223/2009 über kosmetische Mittel, Industrieverband Körperpflege- und Waschmittel e. V. (IKW), Stand: 9.8.2012 (www.ikw.org)
  14. Valenta C, Salbengrundlagen; ÖAZ 2005;16:770-773
  15. Valenta C, Stabilität: Cyproteronacetat in magistralen Zubereitungen, ÖAZ 2002;56:676-678
  16. Wolf G, Höger PH, Dermatologische Basistherapie mit hypoallergenen und noxenfreien Externa im Kindesalter, JDDG 2009;7:50-60
  17. Apothekenbetriebsordnung, Pharmazeutische Zeitung 2012;12;Supplement:1-54
  18. Zipp S, Wareneingangskontrolle von Wirk- und Hilfsstoffen mit dem Fokus auf GMP und regulatorische Anforderungen, Pharm. Ind. 2012;74;4:547-555
  19. Lautenschläger H, Synergien nutzen - Wie Wirkstoffe und Cremebasen Kosmetik und Pharmazie verbinden, Kosmetische Praxis 2010;3:10-12
  20. Lautenschläger H, Übersicht: Behandlung von Problemhäuten, Kosmetik International 2012;8:16-18
  21. Lautenschläger H, Grenzgänger - Kosmetische Pflege auf den Punkt gebracht, Beauty Forum 2010;8:27-29
  22. Lautenschläger H, Gegenüberstellung - kosmetische und pharmazeutische Wirkstoffe, Kosmetik International 2010;10:32-36
  23. Lautenschläger H, Freisetzung und Bioverfügbarkeit - eine Übersicht; Kosmetik & Pflege 2013;1:36-37 (wird fortgesetzt)
  24. Lautenschläger H, Nervensache - erwünschte und unerwünschte Effekte, Kosmetik International 2013;2:40-42
  25. Lautenschläger H, Korneotherapie - Bindeglied zwischen Dermatologie und Kosmetik (ISBN 978-3-00-035755-8), 2011:269-270
  26. 2nd Symposium on Corneotherapy, Langenfeld, 10.-12.5.2013 (www.dermaviduals.de)

Dr. Hans Lautenschläger

Please note: The contribution is based on the state of the art at the revision date.

 
 
 
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